PPD Signs and Symptoms

Sharing is Caring: Does someone you know need to hear about this? Consider sending them this page to show them that help is available.

See if you qualify

Fill out the personal health questions below to see if you meet the basic study requirements. You don’t have to answer any question you don’t want to answer. Your answers will be recorded, but your information will only be used for the purposes of this study.

*Please note that you are also welcome to fill out this form for a loved one who you suspect may be experiencing postpartum depression.

Why participate?

Try an investigational treatment designed to help improve your symptoms

Receive compensation for your time, childcare, formula, and travel

Be a part of helping millions of other mothers with PPD

What’s involved?

  • Fill out the pre-screener above to see if you qualify
  • By the time you receive the treatment, you’ll need to stop breastfeeding and switch to formula-feeding
  • If you qualify, you’ll receive the study treatment, given in two injections around your hip
  • Stay in-patient at the study location for about 72 hours after receiving the injection
  • Go to 12 in-person visits at the study site

For the next 16 days after you get home:

  • Have 12 at-home nurse visits and spend time with a study partner(s) who will be there to support and monitor progress
  • Fill out surveys that take 5 minutes or less 4-6 times a day
  • Wear a smartwatch that can be used, in the case of an emergency, to call emergency medical services. Wear a comfortable arm band that’s used to continually monitor your blood oxygen levels.

Frequently asked questions

What is a “study partner?” What is the investigational treatment? What can I expect for the injection? Who is sponsoring this study? Is there a placebo? Why can’t I breastfeed? What devices do I need to wear?

For this study, you’ll need to have a study partner(s) stay with you at home for the 16 days after you get home from your inpatient stay.

Study partners must be 18+, willing and able to receive a short training, and be there for you or the baby just in case. During that time, if you need to leave home, your study partner will need to go with you.

You will also need a backup study partner just in case.

You could use a combination of two different people- for example, have your partner work from home for 10 days, then have a friend work from home and spend the night for the next 6 days. It’s important to us that you find a system that works best for you and your situation, so please ask your study site if you have any questions. The research site will provide more details and logistics information.

The treatment is called BRII-296. It is thought to work by increasing the levels of serotonin in the brain. This study is evaluating a new, more convenient injection that is designed to be long-lasting, so its effects could potentially last for weeks afterwards.

The treatment is administered via two injections, one into the muscle near each hip, given just a few minutes apart.

The treatment also includes Depo-Medrol, which is commonly used to help reduce pain and inflammation, to help make this as comfortable of an experience as possible.

This study is sponsored by Brii Biosciences, a biotechnology company committed to advancing therapies for significant diseases.

No, in this study there is no placebo. Every participant will receive the same treatment.

Since we haven’t yet looked at how this treatment could affect breastfeeding specifically, we ask that you stop breastfeeding when you receive the treatment. Almost every clinical trial has a similar requirement, to make sure to protect your child.

EMS device- you’ll wear a device (provided) that can easily call EMS in the unlikely event of a medical emergency.

Pulse Oximeter device- this device is about the shape of a watch, and you wear it on your upper arm. It continually monitors your blood oxygen levels. It’s comfortable enough that you’ll probably forget you’re wearing it.

You should wear both devices all the time in the 16 days after you get home from your treatment.