Trial: Comparing Efficacy of Two Treatment Options for Asthma

November 20th, 2019 Posted by Uncategorized 0 thoughts on “Trial: Comparing Efficacy of Two Treatment Options for Asthma”

1nHealth is currently recruiting for a clinical trial tasked with comparing the efficacy of two treatment options intended for adults diagnosed with asthma.

Background: Asthma Impacts Quality of Life

Asthma is a chronic condition characterized by the constricting of airways in the lungs. While the development of asthma most often occurs during childhood, adults are also susceptible to what is considered adult-onset or late-onset asthma. The severity of asthma can range from mild to severe; those with severe asthma often experience a profoundly negative impact on their quality of life. This can be attributed to common symptoms which include shortness of breath, difficulty concentrating, chest pains/tightness, feeling agitated or restless, and muscle fatigue.

Assessing Treatment Options

Long-term asthma-control medications are characteristically proficient in preventing asthma attacks and managing asthma-related symptoms. The following treatment options work to reduce inflammation in the airways, and ultimately keep asthma under control:

  • Inhaled Corticosteroids: Viewed as the most effective treatment option for long-term asthma control, inhaled corticosteroids present low risk of potential side effects. These medications (including fluticasone propionate) are inhaled through the mouth, directly into the lungs.


  • Leukotriene Modifiers: Leukotrienes generate mucus, restricting airways, and causing swelling in the lungs. When taken orally, leukotriene modifiers are effective in relieving asthma symptoms over a 24-hour period. This is accomplished either through targeting leukotriene receptors, or blocking 5-lipoxygenase – an enzyme crucial to the production of leukotrienes.


  • Long-Acting Beta Agonists: Used also in the treatment of COPD, LABAs relax lung muscles and improve airflow. LABAs are classified as an inhaled medication and should be taken with an inhaled corticosteroid to reduce the risk of an asthma attack.


  • Combination Inhalers: A combination inhaler is a mixture of a long-acting beta agonist and a corticosteroid. Although capable of relieving common symptoms, combination inhalers may carry an increased risk of a severe asthma attack.

This clinical trial places an emphasis on exploring the efficacy of a leading branded inhaled corticosteroid compared to that of a pressurized metered-dose inhaler containing fluticasone propionate.

Study Specifics

Recruitment for this clinical trial calls for male/female participants, ages 18 to 75, living in or near Raleigh, NC. Compensation is available for those who complete the clinical trial while demonstrating protocol compliance.

Applying to the study is straightforward, quick, and painless. All you’ll need is access to an internet connection in order to register and complete a brief survey. If you qualify, a member of our study team will contact you to schedule a visit to your nearest clinic location.


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